In the present report, prepared pursuant to Human Rights Council resolution 43/7, the United Nations High Commissioner for Human Rights examines the relationship between the realization of the right to work and the enjoyment of all human rights by persons with disabilities. The report provides an overview of the main barriers persons with disabilities face in enjoying their rights to access and participate in the labour market. It highlights how targeted rights-based measures relating to disability can help overcome these barriers and create an enabling and conducive environment for the participation of persons with disabilities in the labour market.