This practical guide is aimed at assisting States parties to the Convention on the Rights of Persons with Disabilities and other stakeholders, including national human rights institutions and civil society, in understanding the key criteria for the establishment and functioning of independent monitoring frameworks in accordance with the requirements of the Convention and the jurisprudence of the Committee on the Rights of Persons with Disabilities. The preparation of this guide was led by OHCHR, together with the Committee on the Rights of Persons with Disabilities and the United Nations Development Programme through a global initiative supported by the United Nations Partnership on the Rights of Persons with Disabilities. It was developed in consultation with the Global Alliance of National Human Rights Institutions and the International Disability Alliance. The guide addresses key aspects of independent monitoring frameworks through a series of 11 questions related to the purpose and key aspects of independent monitoring frameworks in monitoring the Convention on the Rights of Persons with Disabilities at the national level, including the requirement of independence and the structure, mandate and composition of the frameworks. The guide responds to frequently asked questions on the establishment and functioning of the frameworks, their interaction with other human rights mechanisms, the participation of persons with disabilities and their representative organizations in monitoring the Convention and key elements of monitoring the rights of persons with disabilities under the Convention. The publication also provides examples to assist stakeholders in establishing, operating and engaging in independent monitoring under the Convention.